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Illustration of a medical machine, featuring a main console with a digital display, control buttons, typically used for patient monitoring or diagnostic purposes.

External beam radiotherapy for penile cancer

External beam radiotherapy is a treatment that uses radiation from outside the body to target cancer cells.

It is not commonly used for treating cancer in the penis itself, but it may be considered in advanced cases where the cancer has spread to the lymph nodes in the groin or pelvis, especially after surgery. In these cases, the goal is to reduce the risk of the cancer returning and to help control symptoms like pain or discomfort.

Sometimes, radiotherapy is combined with a medicine called a radiosensitizer, such as cisplatin, which helps make the cancer cells more sensitive to radiation and improves the treatment’s effectiveness.

This chapter contains general information about penile cancer. It is not a substitute for professional medical advice or treatment. Always consult your doctor or healthcare provider for guidance on your individual medical situation.

Last updated: June 2026

Reviewed by (2026 update):

  • Dr. Oscar Brouwer (EAU Guidelines Panel on Penile Cancer)
  • Dr. Walter Cazzaniga (YAU Working Group on Penile & Testis Cancer)