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Hormone replacement therapy is the main treatment for both types of hypogonadism. The goal of hormone replacement therapy (often referred to as testosterone therapy in the case of male hypogonadism) is to help you feel better, improve your mood, boost your energy, and making your muscles and bones stronger.
There are different types of testosterone therapy, and each one is absorbed by the body in its own way, with different possible side effects.
If side effects are a concern, you might want to start with a treatment that’s easy to stop. Ask your doctor which treatment would be right for you in this case.
Not all types of testosterone therapy are available everywhere, so it’s important to work with your doctor to choose the treatment that best fits your needs.
- Primary hypogonadism (problem with the testicles):
Testosterone replacement can bring testosterone levels back to normal. - Secondary hypogonadism (problem starting in the brain):
- In boys, pituitary hormone treatment can help with normal growth and puberty.
- In men who want children, these hormones can boost sperm production and improve fertility.
- In men who don’t wish to have children, testosterone therapy is often used instead. This helps restore testosterone levels, improve symptoms, and support overall health.
This chapter contains general information about male hypogonadism. It is not a substitute for professional medical advice or treatment. Always consult your doctor or healthcare provider for guidance on your individual medical situation.
Last updated: September 2025
Reviewed by:
- Dr. Afonso Morgado (YAU Working Group Sexual and Reproductive Health)